Synthetic Chemist
Yevhenii Vaiser
Bridged nitrogen scaffolds for drug discovery.
3.5 years at Enamine Ltd. — seeking an MSc position in Germany.
01 — About
About
I am a synthetic chemist with 3.5 years of professional experience at Enamine Ltd., Kyiv — one of the world's largest suppliers of screening compounds and building blocks for drug discovery. My work spans the full scale range, from milligram-level discovery synthesis to kilogram production, with a focus on bridged aliphatic scaffolds, particularly azabicyclic compounds of interest to medicinal chemistry programs globally.
My BSc thesis, completed in collaboration with Enamine and Taras Shevchenko National University of Kyiv, introduced a novel synthetic route to 1,4-difunctionalized 7-azabicyclo[2.2.1]heptanes via sequential directed bridgehead lithiation — earning a score of 98/100. I subsequently took part in the Mitacs Globalink Research Internship at the University of Regina, Canada, where I investigated the synthesis of twisted polycyclic aromatic hydrocarbons through α-allylation strategies.
I am looking for an MSc position in Germany in organic or medicinal chemistry — ideally in a group working on synthesis methodology, scaffold design, or drug discovery-oriented chemistry. My long-term goal is a career in the European pharmaceutical industry or academic research.
02 — Research
Research
A Novel Approach to the Synthesis of 1,4-Difunctionalized 7-Azabicyclo[2.2.1]heptanes
Supervisor: Kyrychok O. O.
Developed a new synthetic route to 7-azabicyclo[2.2.1]heptane building blocks bearing functional groups at both bridgehead positions (C-1 and C-4). The key strategy employs sequential directed lithiation (sec-BuLi) of bridgehead carbons followed by electrophilic quench (CO₂), starting from commercially available trans-4-(Boc-amino)cyclohexanol. The protocol delivers quantitative yields and enables access to scaffolds relevant to drug discovery — including epibatidine analogues and nAChR ligands.
Synthesis of Twisted Polycyclic Aromatic Hydrocarbons through α-Allylation
Supervisor: Prof. Marc MacKinnon
Research internship funded by the Mitacs Globalink program. Investigated the synthesis of non-planar twisted PAH frameworks via α-allylation strategies under the supervision of Prof. Marc MacKinnon. Completed October 2025.
Modern Problems of Chemistry — Annual Conference, KNU (2025)
Presented original research on the synthesis of 1,4-difunctionalized 7-azabicyclo[2.2.1]heptanes at the international student and postgraduate conference of the Chemistry Faculty. Conference page: conf.chem.knu.ua.
03 — Experience
Experience
Enamine Ltd.
One of the world's largest suppliers of screening compounds and building blocks for drug discovery. Synthetic Chemist- Design, synthesis, and scale-up of building blocks for pharmaceutical chemistry across milligram to kilogram scales
- Specialization in bridged aliphatic scaffolds — azabicyclic compounds relevant to drug discovery
- Contracted FTE chemist on an R&D collaboration with a major pharmaceutical partner (~1.5 years)
- Applied directed metalation chemistry (sec-BuLi), protecting group strategies (Boc, TBS), and functional group transformations
- Quality control at all synthetic stages; maintained ELN records in Signals Notebook
- Supervised a student intern during the final three months
04 — Education
Education
Taras Shevchenko National University of Kyiv
BSc Chemistry · Chemistry · Organic ChemistryGraduated June 2025. Thesis developed in collaboration with Enamine Ltd.
Notable Coursework
05 — Skills
Skills
Synthetic
Analytical
Software
06 — Languages
Languages
Contact
Get In Touch
I am open to MSc opportunities in Germany and to conversations with research groups working in organic or medicinal chemistry. Feel free to reach out by email.
evaiser2004@gmail.com Download CV