Synthetic Chemist
Yevhenii Vaiser
Organic chemist — from milligram discovery to kilogram production. 3.5 years at Enamine Ltd., Mitacs research intern in Canada. Applying for MSc programs in Germany.
01 — About
About
I am a synthetic chemist with 3.5 years at Enamine Ltd. — one of the world's largest suppliers of building blocks for drug discovery. My daily work ranges from milligram-scale route development to kilogram production using high-pressure equipment, across bridged, spiro, and heterocyclic scaffold classes.
Since January 2025 I have been working as a contracted FTE chemist on an R&D collaboration with a major pharmaceutical partner, focused on route optimization under tight delivery timelines. Before that, my BSc thesis at Taras Shevchenko National University of Kyiv introduced a new approach to 1,4-difunctionalized azabicyclic building blocks — work done jointly with Enamine. In 2025 I completed a Mitacs Globalink research internship at the University of Regina, Canada.
I am applying for MSc programs in Germany in organic or medicinal chemistry, with the goal of building a career in European pharmaceutical R&D or academic research.
02 — Research & Projects
Research & Projects
A Novel Approach to the Synthesis of 1,4-Difunctionalized 7-Azabicyclo[2.2.1]heptanes
Supervisor: Kyrychok O. O.
Developed a new synthetic route to 7-azabicyclo[2.2.1]heptane building blocks bearing functional groups at both bridgehead positions (C-1 and C-4). The key strategy employs sequential directed lithiation (sec-BuLi) of bridgehead carbons followed by electrophilic quench (CO₂), starting from commercially available trans-4-(Boc-amino)cyclohexanol. The protocol delivers quantitative yields and enables access to scaffolds relevant to drug discovery — including epibatidine analogues and nAChR ligands.
Synthesis of Twisted Polycyclic Aromatic Hydrocarbons through α-Allylation
Supervisor: Prof. Marc MacKinnon
Research internship funded by the Mitacs Globalink program. Investigated the synthesis of non-planar twisted PAH frameworks via α-allylation strategies under the supervision of Prof. Marc MacKinnon. Completed October 2025.
Modern Problems of Chemistry — Annual Conference, KNU (2025)
Presented original research on the synthesis of 1,4-difunctionalized 7-azabicyclo[2.2.1]heptanes at the international student and postgraduate conference of the Chemistry Faculty. Conference page: conf.chem.knu.ua.
03 — Experience
Experience
Enamine Ltd.
Chemist- Contracted FTE chemist on an R&D collaboration with a major pharmaceutical partner (CRO model), focused on synthetic route optimization and compound delivery on tight timelines
- Design, synthesis, and scale-up of building blocks for pharmaceutical chemistry across mg to kg scales, using autoclaves, high-pressure reactors, and standard glassware
- Reaction condition optimization (solvent screening, temperature/time profiling, reagent equivalents, catalyst loading) and purification (column chromatography, recrystallization, extraction, filtration)
- Schlenk technique for air/moisture-sensitive chemistry; routine handling of hazardous materials — organometallic compounds, fluorinating reagents, heavy metal reagents, highly corrosive substances
- Distillation: simple, fractional, vacuum
- QC at all stages via HPLC, LC-MS, GC-MS, NMR (¹H/¹³C/¹⁹F, 2D: COSY, NOESY, HMBC, HSQC)
- Supervised a student intern (~6 months): training in synthesis techniques, reaction monitoring, task and reagent management
04 — Education
Education
Taras Shevchenko National University of Kyiv
BSc Chemistry · Chemistry · Organic ChemistryGraduated June 2025. Thesis developed in collaboration with Enamine Ltd.
Notable Coursework
05 — Skills
Skills
Synthetic
Analytical
Software
Equipment
06 — Languages
Languages
Contact
Get In Touch
I am open to MSc opportunities in Germany and to conversations with research groups working in organic or medicinal chemistry. Feel free to reach out by email.
evaiser2004@gmail.com Download CV